Photoinduced nickel-catalyzed reductive acyl cross-coupling: facile access to all carbon quaternary aliphatic ketones
Yukun Chen, Xiaoxiang Xi, Weiming Yuan
Abstract
A photochemical nickel-catalyzed reductive acyl coupling of unstrained tertiary acyl electrophiles with 1°, 2°, and 3°-alkyl radical precursors to synthesize sterically hindered α-tertiary dialkyl ketones is developed.
Topics & Concepts
ChemistryQuaternary carbonNickelCatalysisCoupling (piping)QuaternaryCarbon fibersCoupling reactionPolymer chemistryCombinatorial chemistryOrganic chemistryEnantioselective synthesisMetallurgyComposite numberComposite materialMaterials scienceBiologyPaleontologyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques