Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice
Bingxian Xie, Anjana Murali, Amber Vandevender, Jeffrey Chen, Agustin Gil Silva, Fiona M. Bello, Byron Chuan, Harinath Bahudhanapati, Ian Sipula, Nikolaos Dedousis, Faraaz Shah, Christopher P. O’Donnell, Jonathan K. Alder, Michael J. Jurczak
Abstract
knockout mice results in marked improvements in hyperinsulinemia, hepatic insulin sensitivity, and to a lesser extent peripheral insulin sensitivity. These data support that liver hepatocytes are the primary source of circulating GDF15 in obesity.
Topics & Concepts
GDF15HyperinsulinemiaEndocrinologyInternal medicineHepatocyteInsulinContext (archaeology)Insulin sensitivityBiologyInsulin resistanceMedicineIn vitroBiochemistryPaleontologyGDF15 and Related BiomarkersNutrition and Health in AgingMacrophage Migration Inhibitory Factor