BPHL promotes TNBC stemness by resolving R-loops via POLR2A lactylation inhibition and BARD1-mediated ubiquitination
Quan Yuan, Han Zhang, Naiqian Zhang, Yao Qian, Zhipeng Hong, Xue Wan, Rongjie Ye, Debo Chen, Xiaoling Feng, Ge Yu, Ming Niu
Topics & Concepts
Cancer researchBiologyWnt signaling pathwayUbiquitinBreast cancerCancerCancer stem cellGene silencingTriple-negative breast cancerGenome instabilityEpigeneticsDNA damageStem cellIn vivoImmune checkpointRNA interferenceCancer cellCell cycleChromosome instabilityGeneGene expressionCell biologyDNA repairDownregulation and upregulationCell cycle checkpointCell growthIn vitroRegulation of gene expressionSignal transductionCellDNA methylationLong non-coding RNAmicroRNASuppressorCell cultureTranscriptomeReprogrammingUbiquitin and proteasome pathwaysCell death mechanisms and regulationAcute Myeloid Leukemia Research