MicroRNA in intestinal tight junction regulation
Manmeet Rawat, Prem Kumar Govindappa, Yash Gupta, Y. Thomas
Abstract
MicroRNAs are essential molecules that regulate many biological functions, including intestinal tight junction (TJ) barriers. They regulate pro-inflammatory cytokines, which increase TJ permeability, and anti-inflammatory cytokines, which protect against inflammation and promote intestinal balance. This review explores the role of miRNAs in controlling inflammation and as a potential therapeutic approach for treating IBD and other intestinal disorders. Circulating miRNAs can also serve as biomarkers for intestinal damage and disease progression.
Topics & Concepts
Tight junctionmicroRNACell biologyBiologyGeneticsGeneCancer-related molecular mechanisms researchMicroRNA in disease regulationExtracellular vesicles in disease