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The rheumatoid arthritis drug Auranofin targets peroxiredoxin 1 and peroxiredoxin 2 to trigger ROS-endoplasmic reticulum stress axis-mediated cell death and cytoprotective autophagy

Wenyue Yang, Zhou Zhu, Chaohua Zhou, Junhui Chen, Jinhuan Ou, Haibo Tong, Ashok Iyaswamy, Peng R. Chen, Wei Xu, Chuanbin Yang, Wei Xiao, Jigang Wang, Wei Zhang

2025Free Radical Biology and Medicine11 citationsDOI

Topics & Concepts

Endoplasmic reticulumAutophagyAuranofinRheumatoid arthritisUnfolded protein responseProgrammed cell deathCell biologyMedicinePharmacologyApoptosisChemistryImmunologyBiologyBiochemistryEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and Therapyinterferon and immune responses
The rheumatoid arthritis drug Auranofin targets peroxiredoxin 1 and peroxiredoxin 2 to trigger ROS-endoplasmic reticulum stress axis-mediated cell death and cytoprotective autophagy | Litcius