A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities
Mónica Nardi, Natividad Herrera Cano, Svilen P. Simeonov, Renata Bence, Atanas Kurutos, Rosa Scarpelli, Daniel A. Wunderlin, Antonio Procopio
Abstract
Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic chemistry. The use of non-environmental organic compounds and application high energy synthetic methods, the production of waste, and the application of conventional toxic processes are a problem for the pharmaceutical industry and for these important drugs’ synthesis. The substituted benzimidazoles are summarized in this review to provide insight about their organic synthesis using ecofriendly methods, as well as their pharmacological activities.