Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins
Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Dongdong Li, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, Krishanu Saha, Jon E. Levine, Marina E. Emborg, Shaoqin Gong
Topics & Concepts
Genome editingCRISPRCas9BiologyRibonucleoproteinSubgenomic mRNAGenomeComputational biologyIn vivoGuide RNARNACell biologyGeneticsGeneCRISPR and Genetic EngineeringRNA regulation and diseaseRNA Interference and Gene Delivery