Litcius/Paper detail

A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection

Mariko Kashiwagi, Daniela Salgado Figueroa, Ferhat Ay, Bruce Morgan, Katia Georgopoulos

2022Nature Immunology18 citationsDOIOpen Access PDF

Topics & Concepts

BiologyEnhancerProgenitor cellLymphopoiesisCellular differentiationCell biologyThymocyteTranscription factorT cellProgenitorNegative selectionStem cellGeneticsGeneImmune systemGenomeImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research
A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection | Litcius