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Redox-neutral functionalization of α-Csp<sup>3</sup>–H bonds of secondary cyclic amines: a highly atom-economical strategy for<i>N</i>-arylation/formal cross-dehydrogenative couplings

Priyankar Jha, Saddam Husen, Ravindra Kumar

2021Green Chemistry32 citationsDOI

Abstract

An efficient redox-neutral method has been developed for α-Csp<sup>3</sup>–H functionalization of secondary cyclic amines<italic>via</italic>concurrent<italic>N</italic>-arylation/formal cross dehydrogenation coupling (CDC) with sp<sup>2</sup>-C–H and sp<sup>3</sup>-C–H bonds of arenes and ketones, respectively.

Topics & Concepts

ChemistryDehydrogenationSurface modificationRedoxCyclic aminesAtom (system on chip)Medicinal chemistryAmine gas treatingOrganic chemistryCatalysisPhysical chemistryComputer scienceEmbedded systemCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsRadical Photochemical Reactions
Redox-neutral functionalization of α-Csp<sup>3</sup>–H bonds of secondary cyclic amines: a highly atom-economical strategy for<i>N</i>-arylation/formal cross-dehydrogenative couplings | Litcius