Pan-cancer analysis indicates that MYBL2 is associated with the prognosis and immunotherapy of multiple cancers as an oncogene
Xingjie Chen, Yalin Lu, Hao Yu, Kangjie Du, Yu Zhang, Nan Yang, Qiang Huang
Abstract
T cells, cancer-associated fibroblasts (CAFs) and immune checkpoint-associated cells. Functional enrichment analysis of MYBL2 identified that MYBL2 can play a crucial role in cancers by regulating spliceosomes, DNA replication and the cell cycle. Moreover, we verified the function of MYBL2 in three cancer cells of glioma, breast cancers and liver cancers, and the results showed that MYBL2 can regulate the cell cycle and proliferation ability of cancers.
Topics & Concepts
BiologyCancerOncogeneCancer researchImmunotherapyCancer immunotherapyGeneticsCell cycleFerroptosis and cancer prognosisCancer-related Molecular PathwaysGenetic factors in colorectal cancer