Successful development of a method for the incorporation of Fmoc-Arg(Pbf)-OH in solid-phase peptide synthesis using <i>N</i>-butylpyrrolidinone (NBP) as solvent
Beatriz G. de la Torre, Ashish Kumar, Mahama Alhassan, C. Bucher, Fernando Alberício, John Lopez
Abstract
NBP has proved an excellent alternative solvent to the hazardous DMF for SPPS.
Topics & Concepts
SolventPeptide synthesisSolid-phase synthesisChemistryPhase (matter)Combinatorial chemistryOrganic chemistryPeptideBiochemistryChemical Synthesis and AnalysisClick Chemistry and ApplicationsChemical Synthesis and Reactions