N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination
Christie Mortales, Sung‐Uk Lee, Armen Manousadjian, Ken Hayama, Michael Demetriou
Abstract
1 differentiation and inflammatory demyelination in mice. Thus, N-glycan branching negatively regulates B cell innate function while promoting/maintaining adaptive immunity via BCR, providing an attractive therapeutic target for MS.
Topics & Concepts
Acquired immune systemInnate immune systemEndocytosisCell biologyGlycanBiologyDendritic cellImmunologyCellImmune systemMolecular biologyBiochemistryGlycoproteinGalectins and Cancer BiologyGlycosylation and Glycoproteins ResearchT-cell and B-cell Immunology