Extracellular vesicles from human umbilical cord blood plasma modulate interleukin-2 signaling of T cells to ameliorate experimental autoimmune encephalomyelitis
Sueon Kim, Ji-Young Maeng, Seung‐Joo Hyun, Hyun‐Jung Sohn, Su‐Yeon Kim, Cheol-Hwa Hong, Tai‐Gyu Kim
Abstract
: CBP EVs inhibited T cell proliferation and EAE development by modulating IL-2 signaling and immunosuppressive cell fate. CBP EVs contain critical components for immunosuppression and that CBP EV mimics, specifically those expressing MMP-9 and HSP-72, may offer a novel promising strategy for the treatment of various autoimmune diseases.
Topics & Concepts
Extracellular vesiclesExperimental autoimmune encephalomyelitisExtracellularUmbilical cordImmunologyMedicineEncephalomyelitisCell biologyCytokineInterleukinInflammationChemistryPathologyBiologyMultiple sclerosisExtracellular vesicles in diseaseSystemic Sclerosis and Related DiseasesGalectins and Cancer Biology