Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth
Seungmin Shin, Ji‐Sun Kim, Seong-Wook Park, Sei-Yong Jun, Hye-Jin Kweon, Dong-Ki Choi, Dakeun Lee, Yong Beom Cho, Yong‐Sung Kim
Abstract
We report a potent pan-RAS–targeting antibody and the corresponding therapeutic strategy against RAS mutant tumors.
Topics & Concepts
MutantCytosolAntibodyCancer researchCell biologyBiologyImmunologyGeneticsBiochemistryGeneEnzymeMonoclonal and Polyclonal Antibodies ResearchHER2/EGFR in Cancer ResearchMicrotubule and mitosis dynamics