Early-Onset Colorectal Cancer: A Review of Current Insights and a Call for Action
Shaina Ailawadi, David C. Kaelber, Abbinaya Elangovan
Abstract
While the incidence of colorectal cancer (CRC) in patients above 50 years old has been decreasing over the last several decades, the incidence of CRC among younger patients has been increasing. Early-onset CRC (EO-CRC) is known to exhibit distinct characteristics including specific genetic mutations and modifiable risk factors, which warrants tailored screening and management approaches. This review synthesizes current insights on EO-CRC's epidemiological, genetic, molecular, and clinical features, as well as a call for action for future research on prevention and clinical management.
Topics & Concepts
Colorectal cancerIncidence (geometry)MedicineCall to actionEpidemiologyAction (physics)CancerLynch syndromeOncologyInternal medicineIntensive care medicineBioinformaticsDNA mismatch repairBiologyOpticsPhysicsQuantum mechanicsBusinessMarketingColorectal Cancer Screening and DetectionGenetic factors in colorectal cancerColorectal Cancer Treatments and Studies