Palladium-Catalyzed Diversified Synthesis of Monofluorinated Alkenes from Allylic <i>gem</i>-Difluorides through Pd–OH Intermediate

Abstract

Significant advancements in synthesis of monofluoroalkenes via palladium-catalyzed reactions involving allylic gem -difluorides and diverse nucleophiles have been achieved. This method allows regioselective arylation, alkylation, allylation, alkenylation, and hydrogenation of allylic gem -difluorides, yielding high Z- selectivity and favorable product yields under mild conditions. Tolerating various functional groups, these transformations utilize a common Pd–OH intermediate. Additionally, employing triple Pd-catalyzed cross-coupling yields diverse trisubstituted alkenes efficiently.

Topics & Concepts