A simple and programmable dual-mode aptasensor for the ultrasensitive detection of multidrug-resistant bacteria
Fengfeng Zhao, Mingyuan Zou, Huina Wu, Yuming Yao, Meiling Zhou, Shuo Ma, Feng Xiao, GuliNazhaer Abudushalamu, Yaya Chen, Shijie Cai, Chenyan Yuan, Xiaobo Fan, Xinglu Jiang, Guoqiu Wu
Abstract
in a proof-of-concept experiment. Simultaneously, the Mode-Flu ensured the accuracy of the detection, especially at a high concentration of bacteria. Moreover, the feasibility and universality of the DAPT platform was validated with four other superbugs by simply reprogramming the corresponding sequence. Overall, the proposed DAPT method based on a dual-mode aptasensor can provide a universal platform for the rapid and ultrasensitive detection of pathogenic bacteria due to its superior programmability.
Topics & Concepts
AptamerDual modeDetection limitPathogenic bacteriaBacteriaChemistryNanotechnologyMaterials scienceChromatographyBiologyMolecular biologyEngineeringAerospace engineeringGeneticsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionBacteriophages and microbial interactions