Synthesis and Evaluation of Amide and Thiourea Derivatives as Carbonic Anhydrase (CA) Inhibitors
Zahid Hussain, Abid Mahmood, Qasim Shah, Aqeel Imran, Ehsan Ullah Mughal, Wajiha Khan, Ayesha Baig, Jamshed Iqbal, Amara Mumtaz
Abstract
absorption, distribution, metabolism, and excretion (ADME) studies were performed, which showed that all of the synthesized molecules fulfilled the druggability criteria.
Topics & Concepts
ChemistryADMEAmideThioureaBenzamideCarbonic anhydraseCarbon-13 NMRMorpholineSulfonamideStereochemistryBenzothiazoleDocking (animal)EnzymeMedicinal chemistryOrganic chemistryIn vitroBiochemistryMedicineNursingEnzyme function and inhibitionCholinesterase and Neurodegenerative DiseasesPhenothiazines and Benzothiazines Synthesis and Activities