Parkin plays a crucial role in acute viral myocarditis by regulating mitophagy activity
Yixuan Qiu, Jing Xu, Yilian Chen, Yihao Wu, Yuan-Nan Lin, Weike Liu, Zhening Wang, Yuqing Wu, Xinge Qian, Yuechun Li
Abstract
This study elucidated the important role of Parkin in maintaining cardiac function and inflammatory response by regulating mitophagy activity and the NF-κB pathway during acute VMC. Although the functional impact of mitophagy remains unclear, our findings suggest that Parkin silencing may accelerate VMC development.
Topics & Concepts
MitophagyParkinAutophagyViral MyocarditisMyocarditisPINK1Cell biologyVirologyMedicineBiologyCardiologyInternal medicineDiseaseApoptosisGeneticsParkinson's diseaseViral Infections and Immunology ResearchAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism