Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase
Jiangxin Liu, Jian Ren, Kun Yang, Shuang Chen, Xinni Yang, Qin‐Shi Zhao
Topics & Concepts
Indoleamine 2,3-dioxygenaseChemistryKynurenineKynurenine pathwayEnzymeHeLaBiochemistryTryptophanSurface plasmon resonanceEnzyme kineticsStereochemistryIn vitroActive siteAmino acidNanoparticleMaterials scienceNanotechnologyTryptophan and brain disordersGut microbiota and healthStress Responses and Cortisol