Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded <i>Escherichia coli</i> Combined with Immunogenic Cell Death for Cancer Immunotherapy
Baicheng Wei, Jingmei Pan, Ruiting Yuan, Binfen Shao, Yi Wang, Xing Guo, Shaobing Zhou
Abstract
can greatly polarize M2 macrophages to M1 macrophages, while PDOX-induced ICD can also impair the immunosuppression of the tumor microenvironment. This strategy shows that tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapeutic drugs can commendably enhance the efficacy of immunotherapy.
Topics & Concepts
Tumor microenvironmentMacrophage polarizationImmunotherapyCancer researchImmunosuppressionCancer immunotherapyImmune systemMacrophageImmunologyChemistryMicrobiologyMedicineBiologyIn vitroBiochemistryImmune cells in cancerNanoplatforms for cancer theranosticsCancer Research and Treatments