Bias Investigation in Artificial Intelligence Systems for Early Detection of Parkinson’s Disease: A Narrative Review
Sudip Paul, Mahesh Maindarkar, Sanjay Saxena, Luca Saba, Monika Turk, Manudeep Kalra, Padukode R. Krishnan, Jasjit S. Suri
Abstract
Background and Motivation: Diagnosis of Parkinson's disease (PD) is often based on medical attention and clinical signs. It is subjective and does not have a good prognosis. Artificial Intelligence (AI) has played a promising role in the diagnosis of PD. However, it introduces bias due to lack of sample size, poor validation, clinical evaluation, and lack of big data configuration. The purpose of this study is to compute the risk of bias (RoB) automatically. METHOD: , Roseville, CA, USA), and the mean aggregate score was computed. The studies were ranked and two cutoffs (Moderate-Low (ML) and High-Moderate (MH)) were determined to segregate the studies into three bins: low-, moderate-, and high-bias. RESULT: The ML and HM cutoffs were 3.50 and 2.33, respectively, which constituted 7, 13, and 6 for low-, moderate-, and high-bias studies. The best and worst architectures were "deep learning with sketches as outcomes" and "machine learning with Electroencephalography," respectively. We recommend (i) the usage of power analysis in big data framework, (ii) that it must undergo scientific validation using unseen AI models, and (iii) that it should be taken towards clinical evaluation for reliability and stability tests. CONCLUSION: The AI is a vital component for the diagnosis of early PD and the recommendations must be followed to lower the RoB.