The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
Jiayan Jin, Xiaoxuan Zhao, Huifang Fu, Yuan Gao
Abstract
Yes-associated protein (YAP) is a key effector downstream of the Hippo signaling pathway and plays an important role in the development of the physiology and pathology of the central nervous system (CNS), especially regulating cell proliferation, differentiation, migration, and apoptosis. However, the roles and underlying mechanisms of YAP in CNS diseases are still puzzling. Here, this review will systematically and comprehensively summarize the biological feature, pathological role, and underlying mechanisms of YAP in normal and pathologic CNS, which aims to provide insights into the potential molecular targets and new therapeutic strategies for CNS diseases.
Topics & Concepts
NeuroscienceCentral nervous systemEffectorBiologyHippo signaling pathwayNervous systemMechanism (biology)Cell biologyEpistemologyPhilosophyHippo pathway signaling and YAP/TAZHereditary Neurological DisordersWnt/β-catenin signaling in development and cancer