Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp<sup>3</sup>)–P Bond Formation
Chengkun Li, Ze‐Kun Tao, Adedamola Shoberu, Wei Zhang, Jian‐Ping Zou
Abstract
A CuI-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp3)–P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H–P(O) compounds.
Topics & Concepts
ChemistryCatalysisCopperRadicalAlkylPhosphorusCoupling (piping)Medicinal chemistryOrganic chemistryMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques