De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy
Ryan Mahling, Bence Hegyi, Erin R. Cullen, Timothy M. Cho, Aaron Rodriques, Lucile Fossier, Marc Yehya, Lin Yang, Bi-Xing Chen, Alexander N. Katchman, Nourdine Chakouri, Ruiping Ji, Elaine Y. Wan, Jared Kushner, Steven O. Marx, Sergey Ovchinnikov, Christopher D. Makinson, Donald M. Bers, Manu Ben‐Johny
Topics & Concepts
BiologySodium channelEpilepsyPeptideCell biologySodiumNeuroscienceBiochemistryMaterials scienceMetallurgyCardiac electrophysiology and arrhythmiasIon channel regulation and functionNeuroscience and Neuropharmacology Research