Biological evaluation, radiosensitizing activity and structural insights of novel halogenated quinazoline-sulfonamide conjugates as selective human carbonic anhydrases IX/XII inhibitors
Mostafa M. Ghorab, Aiten M. Soliman, Silvia Bua, Claudiu T. Supuran
Topics & Concepts
ChemistryCarbonic anhydraseCytotoxicitySelectivityGene isoformMoietyDocking (animal)Cell cultureStereochemistryIsozymeQuinazolineBiochemistryStructure–activity relationshipActive siteCytosolEnzymeIn vitroGeneMedicineCatalysisGeneticsNursingBiologyEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities