Ni-catalyzed C–F activation to construct C–P bond with P–P(O) and P(O)OR mediation
Jia Yang, Lei Fan, Chen Chen, Mingyue Wang, Bingqian Sun, Shuai Wang, Hong Zhong, Yongbo Zhou
Abstract
a P(O)OR-mediated pathway, which is barely reported yet. Facile scale-up to the gram level and the upgrading of the bioactive molecule make this protocol to have promising applications in synthetic chemistry.
Topics & Concepts
ArylCatalysisChemistryPhosphorylationMoleculeMedicinal chemistryMediationStereochemistryCombinatorial chemistryBiochemistryOrganic chemistryPolitical scienceLawAlkylFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques