Mannich bases derived from lawsone and their metal complexes: synthetic strategies and biological properties
Abolfazl Olyaei, Mahdieh Sadeghpour, Mehdi Khalaj
Abstract
Lawsone (2-hydroxynaphthalene-1,4-dione) is a natural product which shows significant biological activity. Aminomethylnaphthoquinone Mannich bases derived from lawsone constitute an interesting class of naphthoquinones and/or their metal complexes have demonstrated a series of important biological properties. So, this review aimed to document the publications concerning the synthesis of aminomethylnaphthoquinone Mannich bases from lowsone, aldehydes and amines and their metal complexes using different conditions, and investigation of their applications.
Topics & Concepts
LawsoneChemistryCombinatorial chemistryMetalMannich reactionOrganic chemistryCatalysisBioactive Compounds and Antitumor AgentsSynthesis and Biological EvaluationMetal complexes synthesis and properties