Construction of Pyridine Ring Systems by Mn(OAc)<sub>2</sub>‐Promoted Formal Dehydrative Dehydroaromatizing [4+2] Cycloaddition of Enamides with Maleimides
Xiaolan Li, Xiuqi Zhang, Fukuan Zhang, Xuzhong Luo, Haiqing Luo
Abstract
Abstract Herein, we report a Mn(OAc) 2 ‐promoted formal dehydrative dehydroaromatizing [4+2] cycloaddition of enamides with maleimides for the construction of pyridine rings to access the diverse synthetically valuable pyrrolo[3,4‐c]‐pyridine derivatives. This protocol allows two C−C bond formation for the assembly of pyridine derivatives from enamides synthesizable in two steps and inexpensive maleimides, which exhibits broad substrate scope and good functional group compatibility. magnified image
Topics & Concepts
ChemistryCycloadditionPyridineFormal synthesisRing (chemistry)Combinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsSynthesis and Reactivity of HeterocyclesSynthesis and Catalytic Reactions