Ectopic Tcf1 expression instills a stem-like program in exhausted CD8+ T cells to enhance viral and tumor immunity
Qiang Shan, Shengen Shawn Hu, Xia Chen, Derek B. Danahy, Vladimir P. Badovinac, Chongzhi Zang, Hai‐Hui Xue
Topics & Concepts
Ectopic expressionBiologyStem cellCell biologyTranscriptomeCancer researchKLF4ChromatinTranscription factorGene expressionGeneGeneticsSOX2Immunotherapy and Immune ResponsesCAR-T cell therapy researchImmune Cell Function and Interaction