Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers
Eva M. López‐Vidal, Carly K. Schissel, Somesh Mohapatra, Kamela Bellovoda, Chia-Ling Wu, Jenna Wood, Annika B. Malmberg, Andrei Loas, Rafael Gómez‐Bombarelli, Bradley L. Pentelute
Abstract
was able to deliver an enzyme to the cytosol of cells. Our findings suggest that, given a data set of long CPPs, we can discover by extrapolation short, active sequences that deliver antisense oligomers.
Topics & Concepts
PeptideChemistryIn vivoCell-penetrating peptideOligonucleotideOligomerComputational biologyBiochemistryCell biologyBiologyGeneGeneticsOrganic chemistryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesVirus-based gene therapy research