Design, synthesis, and <i>in silico</i> studies of new quinazolinones tagged thiophene, thienopyrimidine, and thienopyridine scaffolds as antiproliferative agents with potential p38α MAPK kinase inhibitory effects
Aisha A. Alsfouk, Ismail M. M. Othman, Manal M. Anwar, Asmaa Saleh, Eman S. Nossier
Abstract
computer examination of physico-chemical and ADMET properties, the latter analogues seem to be promising candidates for further development and optimization in research.
Topics & Concepts
In silicoThienopyridineInhibitory postsynaptic potentialChemistryMAPK/ERK pathwayThiopheneKinasep38 mitogen-activated protein kinasesPharmacologyMedicineBiochemistryInternal medicineOrganic chemistryAspirinGeneClopidogrelQuinazolinone synthesis and applicationsSynthesis and biological activitySynthesis of Tetrazole Derivatives