Hypoxic preconditioning attenuates ischemia-reperfusion injury in young healthy adults
Caitlin P. Jarrard, Mercedes J. Nagel, Sten Stray‐Gundersen, Hirofumi Tanaka, Sophie Lalande
Abstract
Ischemia-reperfusion injury induced by restoration of blood flow following occlusion impairs flow-mediated dilation, a marker of endothelium-dependent vasodilation. In young healthy adults, exposure to intermittent hypoxia, consisting of alternating short bouts of breathing hypoxic and normoxic air, before an ischemia-reperfusion injury significantly attenuated the reduction in flow-mediated dilation. Thus, hypoxic preconditioning represents a potential strategy to mitigate the effect of ischemia-reperfusion injury associated with ischemic events.
Topics & Concepts
IschemiaMedicineHypoxia (environmental)VasodilationReperfusion injuryCardiologyAnesthesiaIschemic preconditioningOcclusionBlood flowInternal medicineOxygenChemistryOrganic chemistryCardiac Ischemia and ReperfusionCardiac Arrest and ResuscitationHeart Rate Variability and Autonomic Control