Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice
Paula Marincola Smith, Yash A. Choksi, Nicholas O. Markham, David N. Hanna, Jinghuan Zi, Connie Weaver, Jalal A. Hamaamen, Keeli B. Lewis, Jing Yang, Qi Liu, Izumi Kaji, Anna L. Means, R. Daniel Beauchamp
2021American Journal of Physiology-Gastrointestinal and Liver Physiology50 citationsDOIOpen Access PDF
Abstract
We demonstrate that canonical TGFβ family signaling modulates the expression of critical tight junction proteins in colon epithelial cells, and that expression of these tight junction proteins is associated with maintenance of colon epithelial barrier function in mice.
Topics & Concepts
Tight junctionCell biologyBarrier functionFunction (biology)Signal transductionEpitheliumChemistryOccludinBiologyGeneticsBarrier Structure and Function StudiesTGF-β signaling in diseasesFerroptosis and cancer prognosis