Synthesis, characterization, and anticancer potential of pyrene-appended Schiff base tin(<scp>iv</scp>) complexes: experimental and computational insights
Anup Paul, Rais Ahmad Khan, Gouse M. Shaik, Jilani P. Shaik, Dmytro S. Nesterov, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro
Abstract
The cytotoxicity of two novel triorganotin( iv ) compounds featuring pyrene-appended Schiff base groups is demonstrated, and molecular docking analysis indicates that they exhibit interactions with MMP-2 and TGF-β proteins.
Topics & Concepts
ChemistryPyreneSchiff baseTinCytotoxicityCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryIn vitroOrganometallic Compounds Synthesis and CharacterizationMetal complexes synthesis and propertiesCorrosion Behavior and Inhibition