Silver(<scp>i</scp>)-catalyzed selective hydroalkoxylation of C2-alkynyl quinazolinones to synthesize quinazolinone-fused eight-membered N,O-heterocycles
Xiangfei Kong, Xiu-Yun Guo, Zi-Yu Gu, Lin‐Su Wei, Lulu Liu, Dong‐Liang Mo, Cheng‐Xue Pan, Gui‐Fa Su
Abstract
A silver-catalyzed selective 8-<italic>endo-dig</italic>cyclization of C2-alkynyl quinazolinones was developed to prepare a series of novel quinazolinone-fused eight-membered N,O-heterocycles in good-to-excellent yields under mild reaction conditions.
Topics & Concepts
QuinazolinoneChemistryCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryQuinazolinone synthesis and applicationsSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods