Scalable <sup>18</sup> F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [ <sup>18</sup> F]olaparib
Gregory D. Bowden, Nantanat Chailanggar, Bernd J. Pichler, Andreas Maurer
Abstract
F]olaparib, affording the tracer in high radiochemical yields via both manual (%RCY = 78 ± 6%, n = 4 (CMRF step only)) and automated (up to 80% (%RCY); 41% activity yield (%AY)) radiosynthesis procedures.
Topics & Concepts
CopperFluorideScalabilityOlaparibCombinatorial chemistryComputer scienceChemistryRadiochemistryOrganic chemistryInorganic chemistryOperating systemEnzymePoly ADP ribose polymerasePolymeraseLung Cancer Research StudiesRadiopharmaceutical Chemistry and ApplicationsFluorine in Organic Chemistry