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Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice

XU Qing-qin, Haolan Xiong, Wenxiu Zhu, Yiping Liu, Yun Du

2020Life Sciences55 citationsDOI

Topics & Concepts

SepsisOxidative stressLipopolysaccharideCardiac function curvePharmacologySIRT3Intraperitoneal injectionMedicineNitric oxide synthaseATP synthaseChemistryEndocrinologyInternal medicineHeart failureNitric oxideBiochemistryEnzymeSirtuinNAD+ kinaseNeutrophil, Myeloperoxidase and Oxidative MechanismsProtease and Inhibitor MechanismsNitric Oxide and Endothelin Effects
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice | Litcius