Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents
Haoting Zheng, Qiuzi Dai, Zigao Yuan, Tingting Fan, Cunlong Zhang, Zijian Liu, Bizhu Chu, Qinsheng Sun, Yan Chen, Yuyang Jiang
Topics & Concepts
ChemistryAcetylationCancer cellHydroxamic acidHistone deacetylaseQuinazolineCancerHDAC1IC50CytotoxicityBiochemistryPharmacologyCancer researchIn vitroHistoneStereochemistryBiologyGeneticsGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsCancer-related gene regulation