Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy
Geoffrey J. Markowitz, Yi Ban, Diamile A. Tavarez, Liron Yoffe, Enrique Podaza, Yongfeng He, Mitchell Martin, Michael J. Crowley, Tito A. Sandoval, Dingcheng Gao, M. Laura Martín, Olivier Elemento, Juan R. Cubillos‐Ruiz, Timothy E. McGraw, Nasser K. Altorki, Vivek Mittal
Topics & Concepts
RegulatorPentose phosphate pathwayCD8ImmunotherapyCell biologyProgenitorCancer researchProgenitor cellCancer immunotherapyChemistryBiologyGlycolysisImmunologyBiochemistryMetabolismAntigenImmune systemStem cellGeneImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersImmune cells in cancer