Targeting the JAK2/STAT3 Pathway—Can We Compare It to the Two Faces of the God Janus?
Anna Jaśkiewicz, Tomasz Domoradzki, Beata Pająk
Abstract
Muscle cachexia is one of the most critical unmet medical needs. Identifying the molecular background of cancer-induced muscle loss revealed a promising possibility of new therapeutic targets and new drug development. In this review, we will define the signal transducer and activator of transcription 3 (STAT3) protein's role in the tumor formation process and summarize the role of STAT3 in skeletal muscle cachexia. Finally, we will discuss a vast therapeutic potential for the STAT3-inhibiting single-agent treatment innovation that, as the desired outcome, could block tumor growth and generally prevent muscle cachexia.
Topics & Concepts
JanusComputational biologyJanus kinase 2BiologyInternet privacyChemistryCell biologyComputer scienceSignal transductionProgramming languageCytokine Signaling Pathways and InteractionsCancer Mechanisms and Therapyinterferon and immune responses