Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial
Paul Kim, Ana M. Sánchez, Taylor J.R. Penke, Hannah H. Tuson, J. Kime, Robert W. McKee, William L. Slone, Nicholas R. Conley, Lana J. McMillan, Cameron J. Prybol, Paul M. Garofolo
Topics & Concepts
DosingPharmacodynamicsAntibioticsEscherichia coliAntibiotic resistanceUrinary systemMedicineBacteriophagePharmacokineticsDrug resistancePharmacologyMicrobiologyIntensive care medicineBiologyInternal medicineGeneticsGeneCRISPR and Genetic EngineeringBacteriophages and microbial interactionsVibrio bacteria research studies