ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR
Hannah C. Feldman, Rajarshi Ghosh, Vincent C. Auyeung, James L. Mueller, Jae‐Hong Kim, Zachary E. Potter, Venkata N. Vidadala, B. Gayani K. Perera, Alina Olivier, Bradley J. Backes, Julie Zikherman, Feroz R. Papa, Dustin J. Maly
Topics & Concepts
XBP1Unfolded protein responseEndoplasmic reticulumRNase PRNA splicingCell biologyRNase MRPEndoribonucleaseBiologyProtein kinase RProtein kinase AKinaseChemistryBiochemistryRNAMitogen-activated protein kinase kinaseGeneEndoplasmic Reticulum Stress and DiseasePancreatic function and diabetesAutophagy in Disease and Therapy