Optical phased array neural probes for beam-steering in brain tissue
Wesley D. Sacher, Fu-Der Chen, Homeira Moradi-Chameh, Xinyu Liu, Ilan Felts Almog, Thomas Lordello, Michael Chang, Azadeh Naderian, Trevor M. Fowler, Eran Segev, Tianyuan Xue, Sara Mahallati, Taufik A. Valiante, Laurent C. Moreaux, Joyce K. S. Poon, Michael L. Roukes
Abstract
Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering in vitro. Beam formation in brain tissue is simulated and characterized. The probes are used for optogenetic stimulation and calcium imaging.
Topics & Concepts
OptogeneticsMaterials scienceBeam steeringPhased arrayOpticsPhased-array opticsBrain tissueNanophotonicsBeam (structure)Integrated opticsBrain stimulationBiomedical engineeringOptical imagingLaser beamsOptical fiberOptoelectronicsNeural engineeringSiliconLight beamOptical tweezersOptical recordingTwo-photon excitation microscopyOptical forceNeural activityPhotoreceptor and optogenetics researchOrbital Angular Momentum in OpticsNeuroscience and Neural Engineering