High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design
Qingjie Xiao, Ting Xue, Shuai Wen, Chengyong Wu, Zhixiong Zhang, Ting Zhang, Shaoxue Zeng, Bo Sun, Yuxi Wang
Topics & Concepts
TaxaneEpothilonesIxabepiloneEpothiloneTubulinMicrotubuleChemistryBinding siteMechanism of actionStereochemistryBiochemistryBiologyIn vitroCancerCell biologyGeneticsBreast cancerMetastatic breast cancerMicrotubule and mitosis dynamicsCancer Treatment and Pharmacology14-3-3 protein interactions