Synthesis, Biological Evaluation, and <i>In Silico</i> Studies of Novel Coumarin-Based 4<i>H</i>,5<i>H</i>-pyrano[3,2-<i>c</i>]chromenes as Potent β-Glucuronidase and Carbonic Anhydrase Inhibitors
Nadia Arif, Zahid Shafiq, Khalid Mahmood, Muhammad Rafiq, Sadia Naz, Sohail Anjum Shahzad, Umar Farooq, Ali H. Bahkali, Abdallah M. Elgorban, Muhammad Yaqub, Ahmed El‐Gokha
Abstract
docking studies illustrated the significance of substituted groups on the pyranochromene skeleton and binding pattern of these highly potent compounds inside enzyme pockets.
Topics & Concepts
CoumarinIn silicoChemistryCombinatorial chemistryGlucuronidaseStereochemistryBiochemistryOrganic chemistryEnzymeGeneEnzyme function and inhibitionSynthesis and biological activityBioactive Compounds and Antitumor Agents