Pilot Study of Valganciclovir-Induced Leukopenia in Kidney Transplant Recipients With NUDT15 Genetic Variation
Madan M. Bahadur, Nikhil Dhope, R. Kaimal, Ashay Shingare
Abstract
Nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) enzyme is a member of the NUDIX hydrolase enzyme family and inactivates nucleoside triphosphates.S1–S3 NUDT15 poor metabolizer and intermediate metabolizer phenotypes are at increased risk of adverse drug reactions to medications metabolized by the enzyme because of drug levels exceeding the therapeutic range. Apart from azathioprine, another posttransplant medication, ganciclovir is also metabolized by NUDT15.1,2 Valganciclovir, being a prodrug of ganciclovir, will also be metabolized by NUDT15.
Topics & Concepts
ValganciclovirProdrugMedicineThiopurine methyltransferaseLeukopeniaGanciclovirNucleosideEnzymePharmacologyAdverse effectAzathioprineVirologyInternal medicineBiochemistryChemotherapyBiologyVirusDiseaseHuman cytomegalovirusHIV/AIDS drug development and treatmentBiochemical and Molecular ResearchCytomegalovirus and herpesvirus research