IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Heather M. Ren, Elizabeth Motunrayo Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby, Quinn Wade, Shwetank, Ziaur S. M. Rahman, Brian D. Evavold, Aron E. Lukacher
Abstract
High-affinity CD4 T cells produce IL-21 to help CD8 T cells differentiate into tissue-resident memory cells in the brain.
Topics & Concepts
Cytotoxic T cellCD8BiologyCell biologyImmunologyViral infectionInterleukin 21Cellular differentiationVirologyMolecular biologyImmune systemVirusBiochemistryIn vitroGeneImmune Cell Function and InteractionT-cell and B-cell ImmunologyCytomegalovirus and herpesvirus research