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Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis

Rongfei Qin, Pengxu Wang, Bin Wang, Lei Fu, Sarah M. Batt, Gurdyal S. Besra, Chengwei Wu, Yanan Wang, Haihong Huang, Yu Lu, Gang Li

2022European Journal of Medicinal Chemistry16 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryAntimycobacterialDruggabilityLead compoundCytotoxicityDocking (animal)In vivoPharmacologyStructure–activity relationshipDrugBenzothiophenehERGIC50TuberculosisThiopheneMycobacterium tuberculosisStereochemistryIn vitroBiochemistryMedicineNursingGeneEndocrinologyBiotechnologyOrganic chemistryBiologyPotassium channelPathologyTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsComputational Drug Discovery Methods
Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis | Litcius