Intravenous thrombolysis for acute ischemic stroke: From alteplase to tenecteplase
Nan Yang, Hangil Lee, Chuanjie Wu
Abstract
Stroke is one of the primary causes of morbidity and death worldwide. While intravenous (IV) thrombolysis with alteplase has been widely proven to be beneficial for acute ischemic stroke patients, it still has many limitations. Tenecteplase, a revised version of alteplase, is a potential alternative IV thrombolytic agent that has benefits over alteplase. The aim of this mini-review is to summarize the advancements in IV thrombolysis for severe ischemic stroke, specifically the development and transition from alteplase to tenecteplase.
Topics & Concepts
TenecteplaseThrombolysisMedicineFibrinolytic agentStroke (engine)Tissue plasminogen activatorIschemic strokeAcute strokeIntensive care medicineIschemiaCardiologyInternal medicineMyocardial infarctionMechanical engineeringEngineeringAcute Ischemic Stroke ManagementS100 Proteins and AnnexinsTraumatic Brain Injury and Neurovascular Disturbances